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Some of the most potent drugs offer intense but fleeting pleasure. Fentanyl and carfentanil induce an overwhelming euphoria along with strong pain relief, while heroin gives a warm, dreamy sensation. Cocaine and its derivative, crack cocaine, provide an immediate burst of pleasure, self-assurance, and energy, often followed by severe crashes. Methamphetamine delivers a powerful, prolonged high, accompanied by bursts of intense energy, whereas krokodil gives a euphoric experience at the cost of severe physical harm. Synthetic substances like bath salts and flakka trigger a heightened sense of euphoria and social connection but can also lead to paranoia and aggressive outbursts. Meanwhile, PCP creates a sense of detachment and invulnerability.