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Pragmatic trials are trials designed to provide information for real-world clinical practice. They are typically characterized by a focus on the practical aspects of the research design, like the recruitment process and consent, adherence, and the use of routinely available equipment.
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A pragmatic trial that uses a variety investigators and includes participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity, that is crucial for pragmatic trials to be valid and to reduce bias in the results, is also necessary. Too much heterogeneity, however can result in problems with the trial design.
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Mobile compatibility
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Legality
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The aim of pragmatic trials is to replicate real-life scenarios and to achieve maximum validity externally. Usually, they are requested by practitioners and policymakers to inform their decisions. They also provide a useful method of determining the causal relationship between an intervention and its outcomes. However, they should not be used in lieu for the use of explanation trials.
The idea of pragmatism is controversial and there are doubts regarding whether pragmatic trials could be used to replace explanation tests or if they should serve as an addition to them. Schwartz and Lellouch1 made the distinction between explanation studies, which support the physiological hypothesis or clinical hypothesis, and pragmatic trials, that inform policy and practice decision-making. They also suggested an approach to pragmatic trials, called PRECIS.2 This tool was designed to define the features of a pragmatic trial which includes recruitment, design and delivery of the intervention, and the follow-up.
There is a growing trend in the number of pragmatic trials that are published. A recent Medline search using the terms naturalistic and pragmatic, which was limited to controlled trials that are randomized (RCTs) produced 34 articles, shown in red in Figure 2. This is an indication that the health sciences community is becoming more acquaint to the subject of pragmatics. It is important to note, however, that the majority of studies were conducted in primary-care settings.